What Happens During Inflammation?

Inflammation is a set of coordinated actions, I call a "cascade" that comes in response to an "insult".  This could be a surgery, an infection, a virus, a bacteria, burns, disease process, stress. (1)

The endocrine responds with an increased secretion of catecholamines especially epinephrine, glucagon, cortisol, growth hormone and vasopressin, which contributes to the symptoms you feel, like palpitations, hyperglycemia, weakness, dizziness, food intolerance, pain and digestive symptoms. (1)

The immune system responds by releasing inflammatory cytokines that exacerbate the stress response.  The immune system has both the innate system and the adaptive immune system.   It is this adaptive immune system that both works in our favor, but also causes difficulty as its continuously assessing, and adapting to the stressors in the environement.  This is why we have difficulty, thinking we're on track to recovery, but the original and underlying insult hasn't been resolved and adaptations are being made and we morph into different symptoms or symptom variation. (1)

In the case of Lyme, for example, the outer cell membrane has the ability to alter the proteins on their surface as well as coat themselves in a biofilm that helps them avoid detection by the immune system. (2)

All of this cascade process affects normal digestion and functioning and so symptoms arise.  

Listen to the podcast on this information here.


Gropper, S. S., Smith, J. L., & Carr, T. P. (2016). Advanced nutrition and human metabolism (7th ed.). Cengage Learning.

2  Holt, L. (2021, February 3). The Lyme Client and Borrelia Pathology. Retrieved from . https://trinityschool.instructure.com/courses/980/pages/week-2-lecture-the-lyme-client-and-borrelia-pathology


Amanda Plevell, PhD, CNHP is a Natural Health Practitioner with a key interest in Psychoneuroimmunology and autoimmune specific immunology. Find her credentials here, and search the AAANMC for additional information.

Amanda Plevell, PhD and companies are not medical providers or physicians of any kind. We do not heal, treat, cure, attempt to heal, treat, cure, or diagnose any condition. Any and all sources that you choose to employ in your life should be first discussed with your trusted healthcare partner. The information contained in this self help guide are opinions and should not be substituted for medical advice, but are merely a plan based on research and experiences. Likewise, all statements and information in this guidebook, our books, websites, and consultations are for educational purposes and are considered opinion based on concept and belief and should be evaluated by the individual reader for the application to their life. This information and guidance is what we have found to be useful in an easy format to understand. We intend to serve life by submitting this information for your perusal with the highest intention for your and our world’s good. All writings are protected under copyright and all rights are reserved. No distributing or copying for disbursement for any reason without express permission from the author.

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